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A mutation that controls the clinical expression of migraine has been identified

A study conducted by researchers at the University Pompeu Fabra (Barcelona) have identified a mutation that lightens the severity of neurological symptoms associated with migraine. Published in the journal 'Proceedings of the National Academy of Sciences' study first identified a gene that modifies the clinical features of the familiar hemiplegic migraine.

Staff | 13 January 2009

Migraine headache is one of the most frequent and which produces a greater degree of disability, affecting up to 8% of men and up to 20% of women in industrialized countries. The study was led by Jose Manuel Fernandez-Fernandez, a researcher at the Department of Experimental Sciences and Health (CEXS) of the University Pompeu Fabra, in co-operation with researchers from the University of Barcelona and the University Hospital Vall d'Hebron.

The research team identified the mutation in a family where members of three generations suffered from different types of migraine with aura: visual, visual and sensory or familiar hemiplegic.

This work identifies for the first time a gene that modifies the clinical features of familiar hemiplegic migraine. However, this gene modulator which is present in some of these studied patients is the same that can generate this type of migraine in other patients. The difference lies in which mutation it establishes itself.
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